In a routine double contrast lower gastrointestinal (GI) study, if a patient has no known allergies, the two most likely causes of an anaphylactic response would be sensitivity to which substances?

In a routine double contrast lower gastrointestinal (GI) study, the most likely causes of an anaphylactic response, particularly if the patient has no known allergies, would be a sensitivity to latex and barium solution.

Latex allergies are relatively common among a segment of the population and can trigger severe allergic reactions, including anaphylaxis, particularly in medical settings where latex gloves and other devices are frequently used. Barium, while typically considered safe for imaging studies, can occasionally elicit a reaction in sensitive individuals, especially if there is an underlying issue with gastrointestinal tolerance or specific sensitivities.

When combining these two substances, the risk increases for those who might have an undiagnosed sensitivity to latex or an unusual reaction to barium. This makes the combination of latex and barium solution a significant concern in this context.

Other options presented do not align as closely with common sources of anaphylactic reactions. For instance, adhesive tape is not typically associated with systemic allergic reactions leading to anaphylaxis, and while alcohol can cause irritations or reactions, it is generally not a primary trigger in medical contexts. Medical iodine is primarily associated with reactions in situations involving iodinated contrast media for imaging studies but does not apply to a lower GI study focused on